The method of anthropocentric research which is considered to be the leading achievement of linguistics is very important with learning the language phenomena in the language-human-language section. The theme of this article enantiosemic opposition – the polarization between the meanings of one word or phraseologism is also devoted to study on the basis of human factor. In the article the study of opposition of concepts, the factors of the occurrence of enantiosemy is researched on the basis of materials in the Uzbek Language. Up to now in the Uzbek linguistics the lingual opposition has been studied only in the sphere of antonymic and antisemic units, but in the Uzbek language, particularly, in its lexical level there is also another type of opposition, different from the antonymic and antisemic units, it shows the occurrence of oppositional relation in the sphere of one language unit. In the article it is shown that the enantiosemic opposition is very old in the language, it existed in the word even before antonymic opposition. So, there are six factors of the occurrence of enantiosemy in the Uzbek language: 1) the development of the meaning of a word or phraseologism; 2) the communicative-situational purpose of the certain context and the speaker; 3) syntactic sphere of a word or phraseologism; 4) between literary language and dialect; 5) borrowing words from other languages. In the article it is indicated on the basis of the Uzbek language that the occurrence of enantiosemy by means of affixation which is being mentioned by the linguists of the world, and this factor is the important phenomenon in Russian, English, German and other inflected languages,but is originally the result of the development of meaning, enantiosemy doesn’t occur on the basis of this factor. In determining the lingual nature of enantiosemic words in the Uzbek language psycholinguistic, ethnolinguistic, linguocuturological factors particular to uzbek people’s mind served as a basis.